The cartoonist plays on the double meaning of the word 'strip'. If you strip, you take your clothes off (think striptease!). But a strip is also a long street in a city or town, where there are a lot of stores, restaurants, and hotels. Many of the largest hotel, casino and resort properties in the world are located on the Las Vegas Strip.
Pool is a form of billiards. Strip pool is a party game and a variation of the traditional game where players remove an item of clothing whenever their opponent pockets the ball.